Pathophysiology: Concepts of Altered Health States, 8th Edition

This is the Eighth Edition of the comprehensive and well-respected text and reference of pathophysiology. As a nurse-physiologist, Carol Porth uniquely emphasizes “concepts” of altered health states, as opposed to factual descriptions of diseases and disorders. This conceptual model integrates the developmental and preventative aspects of health. By taking this physiologic approach, the author ensures a comprehension of the whole of body function. By integrating all of the aspects of the human body into a total functional whole, the student can grasp both the physical and psychological aspects of altered health.

This edition has a completely revamped art program and new displays that showcase pathophysiological processes though detailed visual representation. Other highlights include a greater international focus, expanded content on evidence-based practice and completely revised, updated chapters on genetics, disorders of white blood cells and lymphoid tissues, and innate and acquired immunity.

A bound-in CD-ROM and companion Website include Weblinks, an NCLEX® tutorial, a Spanish-English audio glossary, monographs of 100 most commonly prescribed drugs, over 30 Concepts in Action animations, 5 Clinical Simulations, and dosage calculation quizzes. An Instructor’s Resource DVD-ROM and online instructor resources are also available.

Key features

  • NEW Understanding…displays showcase key physiological processes and phenomena of a disorder through detailed visual representation. The process is broken down into its consecutive parts, which are presented in a sequential manner, to provide an insight into the many opportunities for disease processes to disrupt the sequence. Each part has a detailed illustration to aid the student.
  • NEW Revamped art program: over 100 of the illustrations in this edition are either new, or have been extensively modified. New clinical manifestation figures for selected disorders
  • NEW Flow charts depicting the interactions among the various mechanisms/body systems Together, the integrated figures, flow charts, understanding feature, and clinical manifestation figures enable the reader to fully understand all aspects of the disorder
  • NEW Review exercises found at the end of each chapter.
  • NEW Chapter 6, Genetics has been rewritten to include new content on human genome project, protein synthesis, transcription factors, RNA silencing.
  • NEW Chapter 15 updated to reflect new materials on leukemia, lymphoma, and multiple myeloma
  • NEW Chapter 17 heavily revised to reflect new science developments
  • NEWAdded content on obesity and the metabolic syndrome. Increased focus on issues and practices relative to the world community, including the inclusion of international studies, WHO guidelines, and the health variants of diverse populations. In line with the greater international focus, the new co-author, Dr. Glenn Matfin, has roots in the United Kingdom, two new contributing authors are from Canada, Charlotte Pooler RN., PhD and Anna Barkman RN, MSN.
  • Integrated pediatric coverage allows for a more streamlined, less redundant text (as opposed to competitive texts, which separate pediatric chapters). Such depth of coverage is more appropriate in Pediatric nursing programs. Pediatric Icons help the reader quickly identify
  • Content has been arranged so that concepts build on one another. Words are defined as content is presented. Concepts from physiology, biochemistry, physics, and other sciences are reviewed along the way.
  • Objectives appear at the beginning of each major section in a chapter, and summaries, with a color screen behind them, are found at section endings. This “chunked” approach encourages the student to pause and review salient points.
  • Intra-text summaries with a color screen behind them are found integrated throughout the text, forcing the student to pause and review salient points. Well-known for its readability, Carol Porth’s writing style is such that she presents information, then continually reinforces difficult concepts.
  • Key Concepts Boxes are designed to help the reader retain and utilize text information by providing a mechanism to incorporate text information into a larger conceptual unit as opposed to memorizing a string of related and unrelated facts.
  • glossary provides a reference of commonly used terms.
  • Helpful lists of common suffixes and prefixes, normal laboratory values in both conventional and SI units, as well as a glossary provide students with useful references.

Publication date: Jul 14, 2010


  • Carol Mattson Porth, RN, MSN, PhD (Physiology), Professor Emerita, College of Nursing, University of Wisconsin—Milwaukee, Milwaukee, Wisconsin
  • Glenn Matfin, BSc (Hons), MB ChB, DGM, FFPM, FACE, FACP, FRCP, Clinical Associate Professor of Medicine, Department of Endocrinology, School of Medicine, New York University, New York, New York

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